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Titel:

Common protein biomarkers assessed by reverse phase protein arrays show considerable intratumoral heterogeneity in breast cancer tissues.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Malinowsky, K; Raychaudhuri, M; Büchner, T; Thulke, S; Wolff, C; Höfler, H; Becker, KF; Avril, S
Abstract:
Proteins are used as prognostic and predictive biomarkers in breast cancer. However, the variability of protein expression within the same tumor is not well studied. The aim of this study was to assess intratumoral heterogeneity in protein expression levels by reverse-phase-protein-arrays (RPPA) (i) within primary breast cancers and (ii) between axillary lymph node metastases from the same patient. Protein was extracted from 106 paraffin-embedded samples from 15 large (>>=3 cm) primary invasive...     »
Zeitschriftentitel:
PLoS ONE
Jahr:
2012
Band / Volume:
7
Heft / Issue:
7
Seitenangaben Beitrag:
e40285
Sprache:
eng
Volltext / DOI:
doi:10.1371/journal.pone.0040285
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/22792263
Print-ISSN:
1932-6203
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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