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Title:

Effects of cold ischemia and inflammatory tumor microenvironment on detection of PI3K/AKT and MAPK pathway activation patterns in clinical cancer samples.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Bonnas, C; Specht, K; Spleiss, O; Froehner, S; Dietmann, G; Krüger, JM; Arbogast, S; Feuerhake, F
Abstract:
The accuracy of common markers for PI3K/AKT and MAPK pathway activation in preclinical and clinical cancer biomarker studies depends on phosphoepitope stability and changes of phosphorylation under ischemia. Herein, we define conditions under which phosphoepitope-specific duplex immunohistochemistry (IHC) on formalin-fixed, paraffin-embedded tumor tissues reflects pathway activation in situ as accurately as possible, and identify activation patterns linked to mutational status, pathway dependenc...     »
Journal title abbreviation:
Int J Cancer
Year:
2012
Journal volume:
131
Journal issue:
7
Pages contribution:
1621-32
Language:
eng
Fulltext / DOI:
doi:10.1002/ijc.27422
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/22213219
Print-ISSN:
0020-7136
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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