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Title:

Human IL-31 is induced by IL-4 and promotes TH2-driven inflammation.

Document type:
Journal Article
Author(s):
Stott, B; Lavender, P; Lehmann, S; Pennino, D; Durham, S; Schmidt-Weber, CB
Abstract:
The pruritic cytokine IL-31 has been shown to be expressed by murine activated effector T Lymphocytes of a TH2 phenotype. Like IL-17 and IL-22, IL-31 is a tissue-signaling cytokine the receptor of which is mainly found on nonimmune cells. An overabundance of IL-31 has been shown in patients with atopic disorders, including dermatitis, as well as asthma, and therefore represents a promising drug target, although its regulation in the context of the human TH2 clusters is not yet known.We sought to...     »
Journal title abbreviation:
J Allergy Clin Immunol
Year:
2013
Journal volume:
132
Journal issue:
2
Pages contribution:
446-454.e5
Language:
eng
Fulltext / DOI:
doi:10.1016/j.jaci.2013.03.050
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/23694808
Print-ISSN:
0091-6749
TUM Institution:
Molekulare Allergologie (Prof. Schmidt-Weber)
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