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Title:

Mechanisms of peripheral tolerance to allergens.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Review
Author(s):
Soyer, OU; Akdis, M; Ring, J; Behrendt, H; Crameri, R; Lauener, R; Akdis, CA
Abstract:
The immune system is regulated to protect the host from exaggerated stimulatory signals establishing a state of tolerance in healthy individuals. The disequilibrium in immune regulatory vs effector mechanisms results in allergic or autoimmune disorders in genetically predisposed subjects under certain environmental conditions. As demonstrated in allergen-specific immunotherapy and in the healthy immune response to high-dose allergen exposure models in humans, T regulatory cells are essential in...     »
Journal title abbreviation:
Allergy
Year:
2013
Journal volume:
68
Journal issue:
2
Pages contribution:
161-70
Language:
eng
Fulltext / DOI:
doi:10.1111/all.12085
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/23253293
Print-ISSN:
0105-4538
TUM Institution:
Klinik und Poliklinik für Dermatologie und Allergologie; Molekulare Allergologie (Prof. Schmidt-Weber)
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