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Titel:

Langerin(neg) conventional dendritic cells produce IL-23 to drive psoriatic plaque formation in mice.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Wohn, Christian; Ober-Blöbaum, Julia L; Haak, Stefan; Pantelyushin, Stanislav; Cheong, Cheolho; Zahner, Sonja P; Onderwater, Sabina; Kant, Marius; Weighardt, Heike; Holzmann, Bernhard; Reizis, Boris; Becher, Burkhard; Prens, Errol P; Clausen, Björn E
Abstract:
Psoriasis is an autoinflammatory skin disease of unknown etiology. Topical application of Aldara cream containing the Toll-like receptor (TLR)7 agonist Imiquimod (IMQ) onto patients induces flares of psoriasis. Likewise, in mice IMQ triggers pathological changes closely resembling psoriatic plaque formation. Key cytokines like IL-23 and type-I IFN (IFN-I), both being produced mainly by dendritic cells (DCs), have been implicated in psoriasis. Although plasmacytoid DCs (pDCs) are the main source...     »
Zeitschriftentitel:
Proc Natl Acad Sci U S A
Jahr:
2013
Band / Volume:
110
Heft / Issue:
26
Seitenangaben Beitrag:
10723-8
Sprache:
eng
Volltext / DOI:
doi:10.1073/pnas.1307569110
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23754427
Print-ISSN:
0027-8424
TUM Einrichtung:
Chirurgische Klinik und Poliklinik; Molekulare Allergologie (Prof. Schmidt-Weber)
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