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Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article 
Autor(en):
Kreutzfeldt, Mario; Bergthaler, Andreas; Fernandez, Marylise; Brück, Wolfgang; Steinbach, Karin; Vorm, Mariann; Coras, Roland; Blumcke, Ingmar; Bonilla, Weldy V; Fleige, Anne; Forman, Ruth; Müller, Werner; Becher, Burkhard; Misgeld, Thomas; Kerschensteiner, Martin; Pinschewer, Daniel D; Merkler, Doron 
Titel:
Neuroprotective intervention by interferon-? blockade prevents CD8+ T cell-mediated dendrite and synapse loss. 
Abstract:
Neurons are postmitotic and thus irreplaceable cells of the central nervous system (CNS). Accordingly, CNS inflammation with resulting neuronal damage can have devastating consequences. We investigated molecular mediators and structural consequences of CD8(+) T lymphocyte (CTL) attack on neurons in vivo. In a viral encephalitis model in mice, disease depended on CTL-derived interferon-? (IFN-?) and neuronal IFN-? signaling. Downstream STAT1 phosphorylation and nuclear translocation in neurons we...    »
 
Zeitschriftentitel:
J Exp Med 
Jahr:
2013 
Band / Volume:
210 
Heft / Issue:
10 
Seitenangaben Beitrag:
2087-103 
Sprache:
eng 
Volltext / DOI:
Print-ISSN:
0022-1007 
TUM Einrichtung:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)