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Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article 
Author(s):
Kreutzfeldt, Mario; Bergthaler, Andreas; Fernandez, Marylise; Brück, Wolfgang; Steinbach, Karin; Vorm, Mariann; Coras, Roland; Blumcke, Ingmar; Bonilla, Weldy V; Fleige, Anne; Forman, Ruth; Müller, Werner; Becher, Burkhard; Misgeld, Thomas; Kerschensteiner, Martin; Pinschewer, Daniel D; Merkler, Doron 
Title:
Neuroprotective intervention by interferon-? blockade prevents CD8+ T cell-mediated dendrite and synapse loss. 
Abstract:
Neurons are postmitotic and thus irreplaceable cells of the central nervous system (CNS). Accordingly, CNS inflammation with resulting neuronal damage can have devastating consequences. We investigated molecular mediators and structural consequences of CD8(+) T lymphocyte (CTL) attack on neurons in vivo. In a viral encephalitis model in mice, disease depended on CTL-derived interferon-? (IFN-?) and neuronal IFN-? signaling. Downstream STAT1 phosphorylation and nuclear translocation in neurons we...    »
 
Journal title abbreviation:
J Exp Med 
Year:
2013 
Journal volume:
210 
Journal issue:
10 
Pages contribution:
2087-103 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
0022-1007 
TUM Institution:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)