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Titel:

Neuroprotective intervention by interferon-? blockade prevents CD8+ T cell-mediated dendrite and synapse loss.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Kreutzfeldt, Mario; Bergthaler, Andreas; Fernandez, Marylise; Brück, Wolfgang; Steinbach, Karin; Vorm, Mariann; Coras, Roland; Blumcke, Ingmar; Bonilla, Weldy V; Fleige, Anne; Forman, Ruth; Müller, Werner; Becher, Burkhard; Misgeld, Thomas; Kerschensteiner, Martin; Pinschewer, Daniel D; Merkler, Doron
Abstract:
Neurons are postmitotic and thus irreplaceable cells of the central nervous system (CNS). Accordingly, CNS inflammation with resulting neuronal damage can have devastating consequences. We investigated molecular mediators and structural consequences of CD8(+) T lymphocyte (CTL) attack on neurons in vivo. In a viral encephalitis model in mice, disease depended on CTL-derived interferon-? (IFN-?) and neuronal IFN-? signaling. Downstream STAT1 phosphorylation and nuclear translocation in neurons we...     »
Zeitschriftentitel:
J Exp Med
Jahr:
2013
Band / Volume:
210
Heft / Issue:
10
Seitenangaben Beitrag:
2087-103
Sprache:
eng
Volltext / DOI:
doi:10.1084/jem.20122143
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23999498
Print-ISSN:
0022-1007
TUM Einrichtung:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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