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Titel:

A novel CXCL10-based GPI-anchored fusion protein as adjuvant in NK-based tumor therapy.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Muenchmeier, Niklas; Boecker, Sophia; Bankel, Lorenz; Hinz, Laura; Rieth, Nicole; Lapa, Constantin; Mendler, Anna N; Noessner, Elfriede; Mocikat, Ralph; Nelson, Peter J
Abstract:
Cellular therapy is a promising therapeutic strategy for malignant diseases. The efficacy of this therapy can be limited by poor infiltration of the tumor by immune effector cells. In particular, NK cell infiltration is often reduced relative to T cells. A novel class of fusion proteins was designed to enhance the recruitment of specific leukocyte subsets based on their expression of a given chemokine receptor. The proteins are composed of an N-terminal chemokine head, the mucin domain taken fro...     »
Zeitschriftentitel:
PLoS ONE
Jahr:
2013
Band / Volume:
8
Heft / Issue:
8
Seitenangaben Beitrag:
e72749
Sprache:
eng
Volltext / DOI:
doi:10.1371/journal.pone.0072749
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24023642
Print-ISSN:
1932-6203
TUM Einrichtung:
Institut für Pharmakologie und Toxikologie
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