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- Dokumenttyp:
- Journal Article; Research Support, Non-U.S. Gov't
- Autor(en):
- Kornek, Matthias; Deutsch, Marcus-André; Eichhorn, Stefan; Lahm, Harald; Wagenpfeil, Stefan; Krane, Markus; Lange, Ruediger; Boehm, Johannes
- Titel:
- COMT-Val158Met-polymorphism is not a risk factor for acute kidney injury after cardiac surgery.
- Abstract:
- Cardiac surgery-associated acute kidney injury (CSA-AKI) depicts a major complication after cardiac surgery using cardiopulmonary bypass (CPB).CSA-AKI has clearly been linked to increased perioperative morbidity and mortality. Dysregulations of vasomotor tone are assumed to be causal for CSA-AKI. While catechol-O-methyltransferase (COMT) is involved in metabolizing catecholamines, a single-nucleotide polymorphism (SNP) in the COMT gene leads to different enzyme activities according to genotype. Pilot studies found associations between those COMT genotypes and CSA-AKI.We prospectively included 1741 patients undergoing elective cardiac surgery using cardiopulmonary bypass (CPB). Patients were genotyped for COMT-Val158Met-(G/A) polymorphism (rs4680).Demographic characteristics and procedural data revealed no significant differences between genotypes. No association between COMT genotypes and the RIFLE criteria could be detected. A multiple linear regression analysis for postoperative creatinine increase revealed highly significant associations for aortic cross-clamp time (P < 0.001), CPB time (P < 0.001), norepinephrine (P < 0.001), and age (P < 0.001). No associations were found for COMT genotypes or baseline creatinine. With an R (2) = 0.39 and a sample size of 1741, the observed power of the regression analysis was >99%.Based on our results, we can rule out an association between the COMT-Val158Met-(G/A) polymorphism and the appearance of CSA-AKI.
- Zeitschriftentitel:
- Dis Markers
- Jahr:
- 2013
- Band / Volume:
- 35
- Heft / Issue:
- 2
- Seitenangaben Beitrag:
- 129-34
- Sprache:
- eng
- Volltext / DOI:
- doi:10.1155/2013/279046
- PubMed:
- http://view.ncbi.nlm.nih.gov/pubmed/24167357
- Print-ISSN:
- 0278-0240
- TUM Einrichtung:
- Institut für Medizinische Statistik und Epidemiologie
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