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Document type:
Journal Article 
Author(s):
Weissbrich, Bianca; Nauerth, Magdalena; Busch, Dirk H 
Title:
Adoptive immunotherapy: New assay for the identification of T cells with optimal avidity. 
Abstract:
T cells expressing high avidity T-cell receptors (TCRs) have been shown to mediate superior therapeutic effects. A novel koff-rate assay allows for the quantitative and reproducible assessment of the avidity of TCRs for their ligands directly on living T cells, ex vivo. This assay might facilitate the selection of T cells with an optimal avidity for their target, hence favoring the development of adoptive immunotherapeutic regimens. 
Journal title abbreviation:
Oncoimmunology 
Year:
2013 
Journal volume:
Journal issue:
10 
Pages contribution:
e26199 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
2162-4011 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene