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Document type:
Journal Article; Research Support, Non-U.S. Gov't 
Author(s):
Römmler, Franziska; Jurk, Marion; Uhlmann, Eugen; Hammel, Monika; Waldhuber, Anna; Pfeiffer, Lavinia; Wagner, Hermann; Vollmer, Jörg; Miethke, Thomas 
Title:
Guanine modification of inhibitory oligonucleotides potentiates their suppressive function. 
Abstract:
Inhibitory TLR7 and/or TLR9 oligonucleotides (inhibitory oligonucleotide [INH-ODN]) are characterized by a phosphorothioate backbone and a CC(T)XXX???GGG motif, respectively. INH-ODN 2088 is a prototypic member of this class of INH-ODN and acts as a TLR7 and TLR9 antagonist. It contains a G quadruple that leads to higher order structures by the formation of G tetrads. These structures are unfavorable for the prediction of their pharmacological and immunological behavior. We show in this study th...    »
 
Journal title abbreviation:
J Immunol 
Year:
2013 
Journal volume:
191 
Journal issue:
Pages contribution:
3240-53 
Language:
eng 
Fulltext / DOI:
Print-ISSN:
0022-1767 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene