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Document type:
Journal Article; Research Support, Non-U.S. Gov't 
Author(s):
Petzold, Tobias; Ruppert, Raphael; Pandey, Dharmendra; Barocke, Verena; Meyer, Hannelore; Lorenz, Michael; Zhang, Lin; Siess, Wolfgang; Massberg, Steffen; Moser, Markus 
Title:
?1 integrin-mediated signals are required for platelet granule secretion and hemostasis in mouse. 
Abstract:
Integrins are critical for platelet adhesion and aggregation during arterial thrombosis and hemostasis. Although the platelet-specific ?IIb?3 integrin is known to be crucial for these processes, the in vivo role of ?1 integrins is a matter of debate. Here we demonstrate that mice expressing reduced levels of ?1 integrins or an activation-deficient ?1 integrin show strongly reduced platelet adhesion to collagen in vitro and in a carotis ligation model in vivo. Interestingly, hypomorphic mice expr...    »
 
Journal title abbreviation:
Blood 
Year:
2013 
Journal volume:
122 
Journal issue:
15 
Pages contribution:
2723-31 
Language:
eng 
Print-ISSN:
0006-4971 
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene