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Titel:

Activation of the NF-kB pathway downregulates TFF-1 in gastric carcinogenesis.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Cobler, Lara; Mejías-Luque, Raquel; Garrido, Marta; Pera, Manuel; Badia-Garrido, Enric; de Bolós, Carme
Abstract:
Trefoil factor 1 (TFF1) is expressed in the normal superficial epithelium of the stomach and is implicated in the maintenance of gastric epithelial structure and function. During gastric carcinogenesis, in which pro-inflammatory cytokines play a crucial role, its expression level decreases suggesting a role as tumor suppressor factor. We have compared expression of TFF1 in gastric mucosa from cancer patients, in which several degrees of inflammatory infiltrate are present, with that in normal mu...     »
Zeitschriftentitel:
Virchows Arch
Jahr:
2013
Band / Volume:
463
Heft / Issue:
4
Seitenangaben Beitrag:
497-507
Sprache:
eng
Volltext / DOI:
doi:10.1007/s00428-013-1469-2
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23942618
Print-ISSN:
0945-6317
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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