Benutzer: Gast  Login
Titel:

Adoptive immunotherapy: New assay for the identification of T cells with optimal avidity.

Dokumenttyp:
Journal Article
Autor(en):
Weissbrich, Bianca; Nauerth, Magdalena; Busch, Dirk H
Abstract:
T cells expressing high avidity T-cell receptors (TCRs) have been shown to mediate superior therapeutic effects. A novel koff-rate assay allows for the quantitative and reproducible assessment of the avidity of TCRs for their ligands directly on living T cells, ex vivo. This assay might facilitate the selection of T cells with an optimal avidity for their target, hence favoring the development of adoptive immunotherapeutic regimens.
Zeitschriftentitel:
Oncoimmunology
Jahr:
2013
Band / Volume:
2
Heft / Issue:
10
Seitenangaben Beitrag:
e26199
Sprache:
eng
Volltext / DOI:
doi:10.4161/onci.26199
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24244903
Print-ISSN:
2162-4011
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
 BibTeX