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Titel:

Prdm6 is essential for cardiovascular development in vivo.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Gewies, Andreas; Castineiras-Vilarino, Mercedes; Ferch, Uta; Jährling, Nina; Heinrich, Katja; Hoeckendorf, Ulrike; Przemeck, Gerhard K H; Munding, Matthias; Groß, Olaf; Schroeder, Timm; Horsch, Marion; Karran, E Loraine; Majid, Aneela; Antonowicz, Stefan; Beckers, Johannes; Hrabé de Angelis, Martin; Dodt, Hans-Ulrich; Peschel, Christian; Förster, Irmgard; Dyer, Martin J S; Ruland, Jürgen
Abstract:
Members of the PRDM protein family have been shown to play important roles during embryonic development. Previous in vitro and in situ analyses indicated a function of Prdm6 in cells of the vascular system. To reveal physiological functions of Prdm6, we generated conditional Prdm6-deficient mice. Complete deletion of Prdm6 results in embryonic lethality due to cardiovascular defects associated with aberrations in vascular patterning. However, smooth muscle cells could be regularly differentiated...     »
Zeitschriftentitel:
PLoS ONE
Jahr:
2013
Band / Volume:
8
Heft / Issue:
11
Seitenangaben Beitrag:
e81833
Sprache:
eng
Volltext / DOI:
doi:10.1371/journal.pone.0081833
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24278461
Print-ISSN:
1932-6203
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Klinische Chemie und Pathobiochemie
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