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Title:

Cellular senescence or EGFR signaling induces Interleukin 6 (IL-6) receptor expression controlled by mammalian target of rapamycin (mTOR).

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Garbers, Christoph; Kuck, Fabian; Aparicio-Siegmund, Samadhi; Konzak, Kirstin; Kessenbrock, Mareike; Sommerfeld, Annika; Häussinger, Dieter; Lang, Philipp A; Brenner, Dirk; Mak, Tak W; Rose-John, Stefan; Essmann, Frank; Schulze-Osthoff, Klaus; Piekorz, Roland P; Scheller, Jürgen
Abstract:
Interleukin 6 (IL-6) signaling plays a role in inflammation, cancer, and senescence. Here, we identified soluble IL-6 receptor (sIL-6R) as a member of the senescence-associated secretory phenotype (SASP). Senescence-associated sIL-6R upregulation was mediated by mammalian target of rapamycin (mTOR). sIL-6R was mainly generated by a disintegrin and metalloprotease 10 (ADAM10)-dependent ectodomain shedding to enable IL-6 trans-signaling. In vivo, heterozygous PTEN-knockout mice exhibited higher mT...     »
Journal title abbreviation:
Cell Cycle
Year:
2013
Journal volume:
12
Journal issue:
21
Pages contribution:
3421-32
Language:
eng
Fulltext / DOI:
doi:10.4161/cc.26431
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24047696
Print-ISSN:
1538-4101
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie
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