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Titel:

Inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural
Autor(en):
Wang, Donghai; Höing, Susanne; Patterson, Heide Christine; Ahmad, Umtul M; Rathinam, Vijay A K; Rajewsky, Klaus; Fitzgerald, Katherine A; Golenbock, Douglas T
Abstract:
Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne Syndrome (PAPA syndrome) is an autoinflammatory disease caused by aberrant production of the proinflammatory cytokine interleukin-1. Mutations in the gene encoding proline serine threonine phosphatase-interacting protein-1 (PSTPIP1) have been linked to PAPA syndrome. PSTPIP1 is an adaptor protein that interacts with PYRIN, the protein encoded by the Mediterranean Fever (MEFV) gene whose mutations cause Familial Mediterranean Fever (FMF). However...     »
Zeitschriftentitel:
J Biol Chem
Jahr:
2013
Band / Volume:
288
Heft / Issue:
7
Seitenangaben Beitrag:
4594-601
Sprache:
eng
Volltext / DOI:
doi:10.1074/jbc.M112.443077
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23293022
Print-ISSN:
0021-9258
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie
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