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Titel:

Independent validation of a prognostic genomic signature (ColoPrint) for patients with stage II colon cancer.

Dokumenttyp:
Journal Article; Validation Studies
Autor(en):
Maak, M; Simón, I; Nitsche, U; Roepman, P; Snel, M; Glas, AM; Schuster, T; Keller, G; Zeestraten, E; Goossens, I; Janssen, KP; Friess, H; Rosenberg, R
Abstract:
The aim of this study was to independently validate a genomic signature developed both to assess recurrence risk in stage II patients and to assist in treatment decisions.Adjuvant therapy is recommended for high-risk patients with stage II colon cancer, but better tools to assess the patients' prognosis accurately are still required.Previously, an 18-gene signature had been developed and validated on an independent cohort, using full genome microarrays. In this study, the gene signature was tran...     »
Zeitschriftentitel:
Ann Surg
Jahr:
2013
Band / Volume:
257
Heft / Issue:
6
Seitenangaben Beitrag:
1053-8
Sprache:
eng
Volltext / DOI:
doi:10.1097/SLA.0b013e31827c1180
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23295318
Print-ISSN:
0003-4932
TUM Einrichtung:
Chirurgische Klinik und Poliklinik; Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Medizinische Statistik und Epidemiologie
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