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Title:

The PI3K/Akt/mTOR Pathway Is Implicated in the Premature Senescence of Primary Human Endothelial Cells Exposed to Chronic Radiation.

Document type:
Journal Article
Author(s):
Yentrapalli, R; Azimzadeh, O; Sriharshan, A; Malinowsky, K; Merl, J; Wojcik, A; Harms-Ringdahl, M; Atkinson, MJ; Becker, KF; Haghdoost, S; Tapio, S
Abstract:
The etiology of radiation-induced cardiovascular disease (CVD) after chronic exposure to low doses of ionizing radiation is only marginally understood. We have previously shown that a chronic low-dose rate exposure (4.1 mGy/h) causes human umbilical vein endothelial cells (HUVECs) to prematurely senesce. We now show that a dose rate of 2.4 mGy/h is also able to trigger premature senescence in HUVECs, primarily indicated by a loss of growth potential and the appearance of the senescence-associate...     »
Journal title abbreviation:
PLoS ONE
Year:
2013
Journal volume:
8
Journal issue:
8
Pages contribution:
e70024
Language:
eng
Fulltext / DOI:
doi:10.1371/journal.pone.0070024
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/23936371
Print-ISSN:
1932-6203
TUM Institution:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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