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Titel:

CX?CL1 (fractalkine) and its receptor CX?CR1 regulate atopic dermatitis by controlling effector T cell retention in inflamed skin.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Staumont-Sallé, Delphine; Fleury, Sébastien; Lazzari, Anne; Molendi-Coste, Olivier; Hornez, Nicolas; Lavogiez, Céline; Kanda, Akira; Wartelle, Julien; Fries, Anissa; Pennino, Davide; Mionnet, Cyrille; Prawitt, Janne; Bouchaert, Emmanuel; Delaporte, Emmanuel; Glaichenhaus, Nicolas; Staels, Bart; Julia, Valérie; Dombrowicz, David
Abstract:
Atopic dermatitis (AD) is a chronic allergic dermatosis characterized by epidermal thickening and dermal inflammatory infiltrates with a dominant Th2 profile during the acute phase, whereas a Th1 profile is characteristic of the chronic stage. Among chemokines and chemokine receptors associated with inflammation, increased levels of CX3CL1 (fractalkine) and its unique receptor, CX3CR1, have been observed in human AD. We have thus investigated their role and mechanism of action in experimental mo...     »
Zeitschriftentitel:
J Exp Med
Jahr:
2014
Band / Volume:
211
Heft / Issue:
6
Seitenangaben Beitrag:
1185-96
Sprache:
eng
Volltext / DOI:
doi:10.1084/jem.20121350
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24821910
Print-ISSN:
0022-1007
TUM Einrichtung:
Molekulare Allergologie (Prof. Schmidt-Weber)
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