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Title:

A recoverable state of axon injury persists for hours after spinal cord contusion in vivo.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Williams, Philip R; Marincu, Bogdan-Nicolae; Sorbara, Catherine D; Mahler, Christoph F; Schumacher, Adrian-Minh; Griesbeck, Oliver; Kerschensteiner, Martin; Misgeld, Thomas
Abstract:
Therapeutic strategies for spinal cord injury (SCI) commonly focus on regenerating disconnected axons. An alternative approach would be to maintain continuity of damaged axons, especially after contusion. The viability of such neuropreservative strategies depends on the degree to which initially injured axons can recover. Here we use morphological and molecular in vivo imaging after contusion SCI in mice to show that injured axons persist in a metastable state for hours. Intra-axonal calcium dyn...     »
Journal title abbreviation:
Nat Commun
Year:
2014
Journal volume:
5
Pages contribution:
5683
Language:
eng
Fulltext / DOI:
doi:10.1038/ncomms6683
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25511170
Print-ISSN:
2041-1723
TUM Institution:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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