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Titel:

A recoverable state of axon injury persists for hours after spinal cord contusion in vivo.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Williams, Philip R; Marincu, Bogdan-Nicolae; Sorbara, Catherine D; Mahler, Christoph F; Schumacher, Adrian-Minh; Griesbeck, Oliver; Kerschensteiner, Martin; Misgeld, Thomas
Abstract:
Therapeutic strategies for spinal cord injury (SCI) commonly focus on regenerating disconnected axons. An alternative approach would be to maintain continuity of damaged axons, especially after contusion. The viability of such neuropreservative strategies depends on the degree to which initially injured axons can recover. Here we use morphological and molecular in vivo imaging after contusion SCI in mice to show that injured axons persist in a metastable state for hours. Intra-axonal calcium dyn...     »
Zeitschriftentitel:
Nat Commun
Jahr:
2014
Band / Volume:
5
Seitenangaben Beitrag:
5683
Sprache:
eng
Volltext / DOI:
doi:10.1038/ncomms6683
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25511170
Print-ISSN:
2041-1723
TUM Einrichtung:
Lehrstuhl für Zellbiologie des Nervensystems (Prof. Misgeld)
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