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Title:

Lowest numbers of primary CD8(+) T cells can reconstitute protective immunity upon adoptive immunotherapy.

Document type:
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Stemberger, Christian; Graef, Patricia; Odendahl, Marcus; Albrecht, Julia; Dössinger, Georg; Anderl, Florian; Buchholz, Veit R; Gasteiger, Georg; Schiemann, Matthias; Grigoleit, Götz U; Schuster, Friedhelm R; Borkhardt, Arndt; Versluys, Birgitta; Tonn, Torsten; Seifried, Erhard; Einsele, Hermann; Germeroth, Lothar; Busch, Dirk H; Neuenhahn, Michael
Abstract:
Patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) are threatened by potentially lethal viral manifestations like cytomegalovirus (CMV) reactivation. Because the success of today's virostatic treatment is limited by side effects and resistance development, adoptive transfer of virus-specific memory T cells derived from the stem cell donor has been proposed as an alternative therapeutic strategy. In this context, dose minimization of adoptively transferred T cells...     »
Journal title abbreviation:
Blood
Year:
2014
Journal volume:
124
Journal issue:
4
Pages contribution:
628-37
Language:
eng
Fulltext / DOI:
doi:10.1182/blood-2013-12-547349
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24855206
Print-ISSN:
0006-4971
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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