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Title:

The triggering receptor expressed on myeloid cells 2 inhibits complement component 1q effector mechanisms and exerts detrimental effects during pneumococcal pneumonia.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Sharif, Omar; Gawish, Riem; Warszawska, Joanna M; Martins, Rui; Lakovits, Karin; Hladik, Anastasiya; Doninger, Bianca; Brunner, Julia; Korosec, Ana; Schwarzenbacher, Roland E; Berg, Tiina; Kralovics, Robert; Colinge, Jacques; Mesteri, Ildiko; Gilfillan, Susan; Salmaggi, Andrea; Verschoor, Admar; Colonna, Marco; Knapp, Sylvia
Abstract:
Phagocytosis and inflammation within the lungs is crucial for host defense during bacterial pneumonia. Triggering receptor expressed on myeloid cells (TREM)-2 was proposed to negatively regulate TLR-mediated responses and enhance phagocytosis by macrophages, but the role of TREM-2 in respiratory tract infections is unknown. Here, we established the presence of TREM-2 on alveolar macrophages (AM) and explored the function of TREM-2 in the innate immune response to pneumococcal infection in vivo....     »
Journal title abbreviation:
PLoS Pathog
Year:
2014
Journal volume:
10
Journal issue:
6
Pages contribution:
e1004167
Language:
eng
Fulltext / DOI:
doi:10.1371/journal.ppat.1004167
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24945405
Print-ISSN:
1553-7366
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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