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Titel:

Lack of host gut microbiota alters immune responses and intestinal granuloma formation during schistosomiasis.

Dokumenttyp:
Journal Article
Autor(en):
Holzscheiter, M; Layland, L E; Loffredo-Verde, E; Mair, K; Vogelmann, R; Langer, R; Wagner, H; Prazeres da Costa, C
Abstract:
Fatalities from schistosome infections arise due to granulomatous, immune-mediated responses to eggs that become trapped in host tissues. Schistosome-specific immune responses are characterized by initial T helper type 1 (Th1) responses and our previous studies demonstrated that myeloid differentiation primary response gene 88 (Myd88)-deficient mice failed to initiate such responses in vivo. Paradoxically, schistosomal antigens fail to stimulate innate cells to release proinflammatory cytokines...     »
Zeitschriftentitel:
Clin Exp Immunol
Jahr:
2014
Band / Volume:
175
Heft / Issue:
2
Seitenangaben Beitrag:
246-57
Sprache:
eng
Volltext / DOI:
doi:10.1111/cei.12230
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24168057
Print-ISSN:
0009-9104
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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