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Title:

Helicobacter pylori-induced IL-1? secretion in innate immune cells is regulated by the NLRP3 inflammasome and requires the cag pathogenicity island.

Document type:
Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Semper, Raphaela P; Mejías-Luque, Raquel; Groß, Christina; Anderl, Florian; Müller, Anne; Vieth, Michael; Busch, Dirk H; Prazeres da Costa, Clarissa; Ruland, Jürgen; Groß, Olaf; Gerhard, Markus
Abstract:
Infection with the gram-negative bacterium Helicobacter pylori is the most prevalent chronic bacterial infection, affecting ~50% of the world's population, and is the main risk factor of gastric cancer. The proinflammatory cytokine IL-1? plays a crucial role in the development of gastric tumors and polymorphisms in the IL-1 gene cluster leading to increased IL-1? production have been associated with increased risk for gastric cancer. To be active, pro-IL-1? must be cleaved by the inflammasome, a...     »
Journal title abbreviation:
J Immunol
Year:
2014
Journal volume:
193
Journal issue:
7
Pages contribution:
3566-76
Language:
eng
Fulltext / DOI:
doi:10.4049/jimmunol.1400362
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25172489
Print-ISSN:
0022-1767
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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