The effects of transjugular intrahepatic portosystemic stent shunt on systemic cardiocirculatory parameters.

Saugel, Bernd; Mair, Sebastian; Meidert, Agnes S; Phillip, Veit; Messer, Marlena; Nennstiel, Simon; Berger, Hermann; Gaa, Jochen; Wagner, Julia Y; Schneider, Heike; Schmid, Roland M; Huber, Wolfgang

doi:10.1016/j.jcrc.2014.06.028

Benutzer: Gast

Institut für Klinische Chemie und Pathobiochemie

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Titel:: The effects of transjugular intrahepatic portosystemic stent shunt on systemic cardiocirculatory parameters.
Dokumenttyp:: Journal Article
Autor(en):: Saugel, Bernd; Mair, Sebastian; Meidert, Agnes S; Phillip, Veit; Messer, Marlena; Nennstiel, Simon; Berger, Hermann; Gaa, Jochen; Wagner, Julia Y; Schneider, Heike; Schmid, Roland M; Huber, Wolfgang
Abstract:: We aimed to evaluate the effects of transjugular intrahepatic portosystemic stent shunt (TIPS) on systemic cardiocirculatory parameters in patients treated with TIPS for portal hypertension-associated complications.This prospective study was conducted in an intensive care unit of a German university hospital (October 2010-July 2013). We assessed hemodynamic parameters before and after TIPS placement using single-indicator transpulmonary thermodilution and pulse contour analysis. After exclusion of 5 patients treated with vasoactive agents during study measurements, 15 patients were included in the final statistical analysis.Transjugular intrahepatic portosystemic stent shunt induced a statistically significant decrease in portal pressure (median, 29 [25%-75% percentile range, 23-37] mm Hg before TIPS vs 21 [18-27] mm Hg after TIPS; P<.01) in parallel with a statistically significant increase in central venous pressure (10 [6-15] mm Hg before TIPS vs 13 [9-16] mm Hg after TIPS; P=.01), cardiac index (3.8 [2.9-4.6] L min(-1) m(-2) before TIPS vs 4.5 [3.8-5.4] L min(-1) m(-2) 14 hours after TIPS; P=.01), and stroke volume index (54 [42-60] mL/m2 before TIPS vs 60 [47-63] mL/m2 14 hours after TIPS; P=.03). Arterial blood pressure and systemic vascular resistance index were statistically significantly lower after TIPS.Transjugular intrahepatic portosystemic stent shunt placement is associated with an increase in central venous pressure and an improvement of global blood flow (cardiac index and stroke volume index) in patients with portal hypertension.
Zeitschriftentitel:: J Crit Care
Jahr:: 2014
Band / Volume:: 29
Heft / Issue:: 6
Seitenangaben Beitrag:: 1001-5
Sprache:: eng
Volltext / DOI:: doi:10.1016/j.jcrc.2014.06.028
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/25220530
Print-ISSN:: 0883-9441
TUM Einrichtung:: II. Medizinische Klinik und Poliklinik (Gastroenterologie); Institut für Klinische Chemie und Pathobiochemie
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