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Title:

The CARD11-BCL10-MALT1 (CBM) signalosome complex: Stepping into the limelight of human primary immunodeficiency.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review; Article
Author(s):
Turvey, Stuart E; Durandy, Anne; Fischer, Alain; Fung, Shan-Yu; Geha, Raif S; Gewies, Andreas; Giese, Thomas; Greil, Johann; Keller, Bärbel; McKinnon, Margaret L; Neven, Bénédicte; Rozmus, Jacob; Ruland, Jürgen; Snow, Andrew L; Stepensky, Polina; Warnatz, Klaus
Abstract:
Next-generation DNA sequencing has accelerated the genetic characterization of many human primary immunodeficiency diseases (PIDs). These discoveries can be lifesaving for the affected patients and also provide a unique opportunity to study the effect of specific genes on human immune function. In the past 18 months, a number of independent groups have begun to define novel PIDs caused by defects in the caspase recruitment domain family, member 11 (CARD11)-B-cell chronic lymphocytic leukemia/lym...     »
Journal title abbreviation:
J Allergy Clin Immunol
Year:
2014
Journal volume:
134
Journal issue:
2
Pages contribution:
276-84
Language:
eng
Fulltext / DOI:
doi:10.1016/j.jaci.2014.06.015
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25087226
Print-ISSN:
0091-6749
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie
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