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Titel:

Falsely elevated cyclosporin and tacrolimus concentrations over prolonged periods of time due to reversible adsorption to central venous catheters.

Dokumenttyp:
Journal Article; Article
Autor(en):
Hacker, Charlotte; Verbeek, Mareike; Schneider, Heike; Steimer, Werner
Abstract:
Falsely elevated concentrations of immunosuppressants can be caused by reversible adsorption to central venous catheter (CVC) systems. If undetected, this may lead to dose reduction resulting in underdosage which may even entail graft-versus-host disease or organ rejection. We analyzed the adsorption and release for cyclosporine A (CsA) and tacrolimus (Tac) in vitro and in vivo. Four types of CVCs were examined in vitro: two made from polyurethane (PU), one from silicone and one from PU with an...     »
Zeitschriftentitel:
Clin Chim Acta
Jahr:
2014
Band / Volume:
433
Seitenangaben Beitrag:
62-8
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.cca.2014.02.031
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24631133
Print-ISSN:
0009-8981
TUM Einrichtung:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Klinische Chemie und Pathobiochemie
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