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Title:

The genomic landscape of hepatoblastoma and their progenies with HCC-like features.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Eichenmüller, Melanie; Trippel, Franziska; Kreuder, Michaela; Beck, Alexander; Schwarzmayr, Thomas; Häberle, Beate; Cairo, Stefano; Leuschner, Ivo; von Schweinitz, Dietrich; Strom, Tim M; Kappler, Roland
Abstract:
Hepatoblastoma (HB) is the most common childhood liver cancer and occasionally presents with histological and clinical features reminiscent of hepatocellular carcinoma (HCC). Identification of molecular mechanisms that drive the neoplastic continuation towards more aggressive HCC phenotypes may help to guide the new stage of targeted therapies.We performed comprehensive studies on genetic and chromosomal alterations as well as candidate gene function and their clinical relevance.Whole-exome sequ...     »
Journal title abbreviation:
J Hepatol
Year:
2014
Journal volume:
61
Journal issue:
6
Pages contribution:
1312-20
Language:
eng
Fulltext / DOI:
doi:10.1016/j.jhep.2014.08.009
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25135868
Print-ISSN:
0168-8278
TUM Institution:
Institut für Humangenetik
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