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Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Fernandes-Rosa, Fabio Luiz; Williams, Tracy Ann; Riester, Anna; Steichen, Olivier; Beuschlein, Felix; Boulkroun, Sheerazed; Strom, Tim M; Monticone, Silvia; Amar, Laurence; Meatchi, Tchao; Mantero, Franco; Cicala, Maria-Verena; Quinkler, Marcus; Fallo, Francesco; Allolio, Bruno; Bernini, Giampaolo; Maccario, Mauro; Giacchetti, Gilberta; Jeunemaitre, Xavier; Mulatero, Paolo; Reincke, Martin; Zennaro, Maria-Christina
Title:
Genetic spectrum and clinical correlates of somatic mutations in aldosterone-producing adenoma.
Abstract:
Primary aldosteronism is the most common form of secondary hypertension. Somatic mutations in KCNJ5, ATP1A1, ATP2B3, and CACNA1D have been described in aldosterone-producing adenomas (APAs). Our aim was to investigate the prevalence of somatic mutations in these genes in unselected patients with APA (n=474), collected through the European Network for the Study of Adrenal Tumors. Correlations with clinical and biochemical parameters were first analyzed in a subset of 199 patients from a single ce...     »
Journal title abbreviation:
Hypertension
Year:
2014
Journal volume:
64
Journal issue:
2
Pages contribution:
354-61
Language:
eng
Fulltext / DOI:
doi:10.1161/HYPERTENSIONAHA.114.03419
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24866132
Print-ISSN:
0194-911X
TUM Institution:
Institut für Humangenetik
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