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Titel:

The genomic landscape of hepatoblastoma and their progenies with HCC-like features.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Eichenmüller, Melanie; Trippel, Franziska; Kreuder, Michaela; Beck, Alexander; Schwarzmayr, Thomas; Häberle, Beate; Cairo, Stefano; Leuschner, Ivo; von Schweinitz, Dietrich; Strom, Tim M; Kappler, Roland
Abstract:
Hepatoblastoma (HB) is the most common childhood liver cancer and occasionally presents with histological and clinical features reminiscent of hepatocellular carcinoma (HCC). Identification of molecular mechanisms that drive the neoplastic continuation towards more aggressive HCC phenotypes may help to guide the new stage of targeted therapies.We performed comprehensive studies on genetic and chromosomal alterations as well as candidate gene function and their clinical relevance.Whole-exome sequ...     »
Zeitschriftentitel:
J Hepatol
Jahr:
2014
Band / Volume:
61
Heft / Issue:
6
Seitenangaben Beitrag:
1312-20
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.jhep.2014.08.009
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25135868
Print-ISSN:
0168-8278
TUM Einrichtung:
Institut für Humangenetik
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