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- Title:
Interim endoscopy results during neoadjuvant therapy for gastric cancer correlate with histopathological response and prognosis.
- Document type:
- Journal Article; Research Support, Non-U.S. Gov't
- Author(s):
- Heger, U; Bader, F; Lordick, F; Burian, M; Langer, R; Dobritz, M; Blank, S; Bruckner, T; Becker, K; Herrmann, K; Siewert, JR; Ott, K
- Abstract:
- Neoadjuvant chemotherapy for locally advanced gastric cancer leads to major histopathological response in less than 30 % of patients. Data on interim endoscopic response assessment do not exist. This exploratory prospective study evaluates early endoscopy after 50 % of the chemotherapy as predictor for later response and prognosis.Forty-seven consecutive patients were included (45 resected; 33 R0 resections). All patients received baseline endoscopy and CT scans, after 50 % of their chemotherapy (EGD-1, CT-1) and after completion of chemotherapy (EGD-2, CT-2). Interim endoscopic response (EGD-1) was assessed after having received 50 % (6 weeks) of the planned 12 weeks of neoadjuvant chemotherapy. Post-chemotherapy response was clinically assessed by a combination of CT scan (CT-2) and endoscopy (EGD-2). Histopathological response was determined by a standardized scoring system (Becker criteria). Endoscopic response was defined as a reduction of >75 % of the tumor mass.Twelve patients were responders at EGD-1 and 13 at EGD-2. Nine patients (19.1 %) were clinical responders and 7 patients (15.6 %) were histopathological responders after chemotherapy. Specificity, accuracy, and negative predictive value of the interim EGD-1 for subsequent histopathological response were 31/38 (82 %), 36/47 (76 %), and 31/33 (93 %); and for recurrence or death, 28/30 (93.3 %), 38/47 (80.9 %), and 28/35 (80.0 %). Response at EGD-1 was significantly associated with histopathological response (p = 0.010), survival (p < 0.001), and recurrence-free survival (p = 0.009).Interim endoscopy after 6 weeks predicts response and prognosis. Therefore, tailoring treatment according to interim endoscopic assessment could be feasible, but the findings of this study should be validated in a larger patient cohort.
- Journal title abbreviation:
- Gastric Cancer
- Year:
- 2014
- Journal volume:
- 17
- Journal issue:
- 3
- Pages contribution:
- 478-88
- Language:
- eng
- Fulltext / DOI:
- doi:10.1007/s10120-013-0296-0
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/23996162
- Print-ISSN:
- 1436-3291
- TUM Institution:
- Institut für Allgemeine Pathologie und Pathologische Anatomie
BibTeX
Occurrences:
- mediaTUM GesamtbestandEinrichtungenHochschulpräsidiumTUM Senior Excellence FacultyEoE Publikationen2014