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Title:

Colonic expression of the peptide transporter PEPT1 is downregulated during intestinal inflammation and is not required for NOD2-dependent immune activation.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Article
Author(s):
Wuensch, Tilo; Ullrich, Sina; Schulz, Stephan; Chamaillard, Mathias; Schaltenberg, Nicola; Rath, Eva; Goebel, Ulf; Sartor, R Balfour; Prager, Matthias; Büning, Carsten; Bugert, Peter; Witt, Heiko; Haller, Dirk; Daniel, Hannelore
Abstract:
PEPT1 was proposed to be expressed only in inflamed colonic tissues in which it could contribute to inflammatory bowel disease (IBD) development by transporting bacterial peptides, such as muramyl dipeptide (MDP), that activate intracellular pattern recognition receptors, such as the nucleotide-binding and oligomerization domain 2. To better define the pathological relevance of this transporter, we analyzed PEPT1 expression during intestinal inflammation and studied the susceptibility of Pept1-d...     »
Journal title abbreviation:
Inflamm Bowel Dis
Year:
2014
Journal volume:
20
Journal issue:
4
Pages contribution:
671-84
Language:
eng
Fulltext / DOI:
doi:10.1097/01.MIB.0000443336.71488.08
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24583477
Print-ISSN:
1078-0998
TUM Institution:
Else Kröner-Fresenius-Zentrum für Ernährungsmedizin - Klinik für Ernährungsmedizin
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