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Titel:

MicroRNAs coordinately regulate protein complexes

Autor(en):
Sass, S.; Dietmann, S.; Burk, U. C.; Brabletz, S.; Lutter, D.; Kowarsch, A.; Mayer, K. F. X.; Brabletz, T.; Ruepp, A.; Theis, F. J.; Wang, Y.
Abstract:
BACKGROUND: In animals, microRNAs (miRNAs) regulate the protein synthesis of their target messenger RNAs (mRNAs) by either translational repression or deadenylation. miRNAs are frequently found to be co-expressed in different tissues and cell types, while some form polycistronic clusters on genomes. Interactions between targets of co-expressed miRNAs (including miRNA clusters) have not yet been systematically investigated.RESULTS: Here we integrated information from predicted and experimentally...     »
Stichworte:
mir-200 family interaction network mesenchymal transition repressors zeb1 cancer-cells drosophila expression evolution cluster genes
Zeitschriftentitel:
BMC Syst. Biol.
Jahr:
2011
Band / Volume:
5
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