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Title:

MicroRNAs coordinately regulate protein complexes

Author(s):
Sass, S.; Dietmann, S.; Burk, U. C.; Brabletz, S.; Lutter, D.; Kowarsch, A.; Mayer, K. F. X.; Brabletz, T.; Ruepp, A.; Theis, F. J.; Wang, Y.
Abstract:
BACKGROUND: In animals, microRNAs (miRNAs) regulate the protein synthesis of their target messenger RNAs (mRNAs) by either translational repression or deadenylation. miRNAs are frequently found to be co-expressed in different tissues and cell types, while some form polycistronic clusters on genomes. Interactions between targets of co-expressed miRNAs (including miRNA clusters) have not yet been systematically investigated.RESULTS: Here we integrated information from predicted and experimentally...     »
Keywords:
mir-200 family interaction network mesenchymal transition repressors zeb1 cancer-cells drosophila expression evolution cluster genes
Journal title:
BMC Syst. Biol.
Year:
2011
Journal volume:
5
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