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Titel:

Are we to integrate previous information into microarray analyses? Interpretation of a Lmx1b-knockout experiment

Autor(en):
Blöchl, F.; Rascle, A.; Kastner, J.; Witzgall, R.; Lang, E. W.; Theis, F. J.
Abstract:
A general question in the analysis of biological experiments is how to maximize statistical information present in the data while at the same time keeping bias at a minimal level. This can be reformulated as the question whether to perform differential analysis or only explorative screens. In this contribution we discuss this old paradigm in the context of a differential microarray experiment. The transcription factor Lmx1b is knocked out in a mouse model in order to gain further insight into ge...     »
Seitenangaben Beitrag:
157-170
Stichworte:
Microarray analysis Nail-patella syndrome Lmx1b inear mixing models recursive feature extraction
Herausgeber:
Gorriz, J. M.; Lang, E. W.; Ramirez, J.
Verlag / Institution:
Bentham Science Publishers
Verlagsort:
Hilversum
Jahr:
2011
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