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Title:

Hydrogen bonds in membrane proteins

Author(s):
Sheu, Sheh-Yi; Schlag, Edward W.; Selzle, Heinrich L.; Yang, Dah-Yen
Abstract:
H-bonds are essential tie points inside protein structures. They undergo dynamic rupture and rebonding processes on the time scale of tens of picoseconds. Proteins can partially rearrange during such ruptures. In previous work, the authors performed mol. dynamics simulations of these fluctuating H-bonds. This indicated long-range entropy and energy contributions extending far into the liq. environment. The results showed that the binding of a given H-bond was much reduced as a result of these in...     »
Keywords:
Proteins Role: BSU (Biological study, unclassified), PRP (Properties), BIOL (Biological study) (membrane models for hydrogen bonds in membrane proteins) Hydrogen bond (models for hydrogen bonds in membrane proteins) Peptides Role: BSU (Biological study, unclassified), PEP (Physical, engineering or chemical process), PRP (Properties), BIOL (Biological study), PROC (Process) (models of peptide hydrogen bonds in lipid environment) Simulation and Modeling (mol. dynamics of peptide hydrogen bonds in...     »
Congress title:
CAN 150:346979 6-3 General Biochemistry Department of Life Sciences and Institute of Biomedical Informatics, National Yang-Ming University, Taipei, Taiwan. Journal 1520-6106 37231-28-0 (Melittin) Role: BSU (Biological study, unclassified), PEP (Physical, engineering or chemical process), PRP (Properties), BIOL (Biological study), PROC (Process) (models of peptide hydrogen bonds in lipid environment)
Journal title:
J. Phys. Chem. B
Year:
2009
Journal volume:
113
Journal issue:
15
Pages contribution:
5318-5326
Fulltext / DOI:
doi:10.1021/jp810772a
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