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Titel:

PTK 7 is a transforming gene and prognostic marker for breast cancer and nodal metastasis involvement.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Gartner, Silvia; Gunesch, Angela; Knyazeva, Tatiana; Wolf, Petra; Högel, Bernhard; Eiermann, Wolfgang; Ullrich, Axel; Knyazev, Pjotr; Ataseven, Beyhan
Abstract:
Protein Tyrosin Kinase 7 (PTK7) is upregulated in several human cancers; however, its clinical implication in breast cancer (BC) and lymph node (LN) is still unclear. In order to investigate the function of PTK7 in mediating BC cell motility and invasivity, PTK7 expression in BC cell lines was determined. PTK7 signaling in highly invasive breast cancer cells was inhibited by a dominant-negative PTK7 mutant, an antibody against the extracellular domain of PTK7, and siRNA knockdown of PTK7. This...     »
Zeitschriftentitel:
PLoS ONE
Jahr:
2014
Band / Volume:
9
Heft / Issue:
1
Seitenangaben Beitrag:
e84472
Sprache:
eng
Volltext / DOI:
doi:10.1371/journal.pone.0084472
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/24409301
Print-ISSN:
1932-6203
TUM Einrichtung:
Institut für Medizinische Statistik und Epidemiologie
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