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Title:

The role of dendritic cells in autoimmunity.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
Author(s):
Ganguly, Dipyaman; Haak, Stefan; Sisirak, Vanja; Reizis, Boris
Abstract:
Dendritic cells (DCs) initiate and shape both the innate and adaptive immune responses. Accordingly, recent evidence from clinical studies and experimental models implicates DCs in the pathogenesis of most autoimmune diseases. However, fundamental questions remain unanswered concerning the actual roles of DCs in autoimmunity, both in general and, in particular, in specific diseases. In this Review, we discuss the proposed roles of DCs in immunological tolerance, the effect of the gain or loss of...     »
Journal title abbreviation:
Nat Rev Immunol
Year:
2013
Journal volume:
13
Journal issue:
8
Pages contribution:
566-77
Language:
eng
Fulltext / DOI:
doi:10.1038/nri3477
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/23827956
Print-ISSN:
1474-1733
TUM Institution:
Molekulare Allergologie (Prof. Schmidt-Weber)
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