Despite the steady improvement of breast cancer therapy, the prognosis for triple negative breast cancer (TNBC) remains poor. TNBC shows significant overexpression of miR-221, which is associated with poor prognosis. By regulating cellular processes, miR-221 is heavily involved in tumor pathogenesis. The interaction of miR-221 overexpression with radiation and its influence on migration, proliferation and colony formation were here further investigated. Regarding the consequences for a personalized radiotherapy in the future, miR-221 overexpression in TNBC patients could be used as biomarker for a higher migration potential.
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Despite the steady improvement of breast cancer therapy, the prognosis for triple negative breast cancer (TNBC) remains poor. TNBC shows significant overexpression of miR-221, which is associated with poor prognosis. By regulating cellular processes, miR-221 is heavily involved in tumor pathogenesis. The interaction of miR-221 overexpression with radiation and its influence on migration, proliferation and colony formation were here further investigated. Regarding the consequences for a personali...
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