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Titel:

A folding switch regulates interleukin 27 biogenesis and secretion of its α-subunit as a cytokine.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Müller, Stephanie I; Friedl, Antonie; Aschenbrenner, Isabel; Esser-von Bieren, Julia; Zacharias, Martin; Devergne, Odile; Feige, Matthias J
Abstract:
A common design principle of heteromeric signaling proteins is the use of shared subunits. This allows encoding of complex messages while maintaining evolutionary flexibility. How cells regulate and control assembly of such composite signaling proteins remains an important open question. An example of particular complexity and biological relevance is the interleukin 12 (IL-12) family. Four functionally distinct αβ heterodimers are assembled from only five subunits to regulate immune cell functio...     »
Zeitschriftentitel:
Proc Natl Acad Sci U S A
Jahr:
2019
Band / Volume:
116
Heft / Issue:
5
Seitenangaben Beitrag:
1585-1590
Volltext / DOI:
doi:10.1073/pnas.1816698116
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30651310
Print-ISSN:
0027-8424
TUM Einrichtung:
Molekulare Allergologie (Prof. Schmidt-Weber)
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