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Title:

Hematopoietic ChemR23 (Chemerin Receptor 23) Fuels Atherosclerosis by Sustaining an M1 Macrophage-Phenotype and Guidance of Plasmacytoid Dendritic Cells to Murine Lesions-Brief Report.

Document type:
Article; Journal Article; Research Support, Non-U.S. Gov't
Author(s):
van der Vorst, Emiel P C; Mandl, Manuela; Müller, Madeleine; Neideck, Carlos; Jansen, Yvonne; Hristov, Michael; Gencer, Selin; Peters, Linsey J F; Meiler, Svenja; Feld, Micha; Geiselhöringer, Anna-Lena; de Jong, Renske J; Ohnmacht, Caspar; Noels, Heidi; Soehnlein, Oliver; Drechsler, Maik; Weber, Christian; Döring, Yvonne
Abstract:
Objective- Expression of the chemokine-like receptor ChemR23 (chemerin receptor 23) has been specifically attributed to plasmacytoid dendritic cells (pDCs) and macrophages and ChemR23 has been suggested to mediate an inflammatory immune response in these cells. Because chemokine receptors are important in perpetuating chronic inflammation, we aimed to establish the role of ChemR23-deficiency on macrophages and pDCs in atherosclerosis. Approach and Results- ChemR23-knockout/knockin mice expressin...     »
Journal title abbreviation:
Arterioscler Thromb Vasc Biol
Year:
2019
Journal volume:
39
Journal issue:
4
Pages contribution:
685-693
Fulltext / DOI:
doi:10.1161/ATVBAHA.119.312386
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30786742
Print-ISSN:
1079-5642
TUM Institution:
Molekulare Allergologie (Prof. Schmidt-Weber)
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