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Titel:

A novel cell-free method to culture Schistosoma mansoni from cercariae to juvenile worm stages for in vitro drug testing.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Frahm, Sören; Anisuzzaman, Anisuzzaman; Prodjinotho, Ulrich Fabien; Vejzagić, Nermina; Verschoor, Admar; Prazeres da Costa, Clarissa
Abstract:
BACKGROUND: The arsenal in anthelminthic treatment against schistosomiasis is limited and relies almost exclusively on a single drug, praziquantel (PZQ). Thus, resistance to PZQ could constitute a major threat. Even though PZQ is potent in killing adult worms, its activity against earlier stages is limited. Current in vitro drug screening strategies depend on newly transformed schistosomula (NTS) for initial hit identification, thereby limiting sensitivity to new compounds predominantly active i...     »
Zeitschriftentitel:
PLoS Negl Trop Dis
Jahr:
2019
Band / Volume:
13
Heft / Issue:
1
Volltext / DOI:
doi:10.1371/journal.pntd.0006590
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30689639
Print-ISSN:
1935-2727
TUM Einrichtung:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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