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Title:

A novel cell-free method to culture Schistosoma mansoni from cercariae to juvenile worm stages for in vitro drug testing.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Frahm, Sören; Anisuzzaman, Anisuzzaman; Prodjinotho, Ulrich Fabien; Vejzagić, Nermina; Verschoor, Admar; Prazeres da Costa, Clarissa
Abstract:
BACKGROUND: The arsenal in anthelminthic treatment against schistosomiasis is limited and relies almost exclusively on a single drug, praziquantel (PZQ). Thus, resistance to PZQ could constitute a major threat. Even though PZQ is potent in killing adult worms, its activity against earlier stages is limited. Current in vitro drug screening strategies depend on newly transformed schistosomula (NTS) for initial hit identification, thereby limiting sensitivity to new compounds predominantly active i...     »
Journal title abbreviation:
PLoS Negl Trop Dis
Year:
2019
Journal volume:
13
Journal issue:
1
Fulltext / DOI:
doi:10.1371/journal.pntd.0006590
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30689639
Print-ISSN:
1935-2727
TUM Institution:
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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