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Title:

Protein Kinase G Is Involved in Acute but Not in Long-Term Regulation of Renin Secretion.

Document type:
Article; Journal Article
Author(s):
Schramm, Andrea; Schweda, Frank; Sequeira-Lopez, Maria Luisa S; Hofmann, Franz; Sandner, Peter; Schlossmann, Jens
Abstract:
Pharmacological inhibition of the renin-angiotensin-aldosterone system (RAAS) is, in combination with diuretics, the first-choice treatment for hypertension, although 10-20% of patients do not respond adequately. Next to the RAAS, the nitric oxide/cGMP/protein kinase G (PKG) system is the second fundamental blood pressure regulator. Whether both systems influence each other is not well-studied. It has been shown that nitric oxide (NO) supports renin recruitment via activation of soluble guanylat...     »
Journal title abbreviation:
Front Pharmacol
Year:
2019
Journal volume:
10
Fulltext / DOI:
doi:10.3389/fphar.2019.00800
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31379575
TUM Institution:
Institut für Pharmakologie und Toxikologie
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