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Titel:

Cell Type-Specific Human APP Transgene Expression by Hippocampal Interneurons in the Tg2576 Mouse Model of Alzheimer's Disease.

Dokumenttyp:
Journal Article
Autor(en):
Höfling, Corinna; Shehabi, Emira; Kuhn, Peer-Hendrik; Lichtenthaler, Stefan F; Hartlage-Rübsamen, Maike; Roßner, Steffen
Abstract:
Amyloid precursor protein (APP) transgenic animal models of Alzheimer's disease have become versatile tools for basic and translational research. However, there is great heterogeneity of histological, biochemical, and functional data between transgenic mouse lines, which might be due to different transgene expression patterns. Here, the expression of human APP (hAPP) by GABAergic hippocampal interneurons immunoreactive for the calcium binding proteins parvalbumin, calbindin, calretinin, and for...     »
Zeitschriftentitel:
Front Neurosci
Jahr:
2019
Band / Volume:
13
Seitenangaben Beitrag:
137
Sprache:
eng
Volltext / DOI:
doi:10.3389/fnins.2019.00137
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30853883
Print-ISSN:
1662-4548
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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