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Title:

The ParaHox gene Cdx4 induces acute erythroid leukemia in mice

Document type:
Article
Author(s):
Thoene, Silvia; Mandal, Tamoghna; Vegi, Naidu M.; Quintanilla-Martinez, Leticia; Roesler, Reinhild; Wiese, Sebastian; Metzeler, Klaus H.; Herold, Tobias; Haferlach, Torsten; Doehner, Konstanze; Doehner, Hartmut; Schwarzmueller, Luisa; Klingmueller, Ursula; Buske, Christian; Rawat, Vijay P. S.; Feuring-Buske, Michaela
Abstract:
Acute erythroid leukemia (AEL) is a rare and aggressive form of acute leukemia, the biology of which remains poorly understood. Here we demonstrate that the ParaHox gene CDX4 is expressed in patients with acute erythroid leukemia, and that aberrant expression of Cdx4 induced homogenously a transplantable acute erythroid leukemia in mice. Gene expression analyses demonstrated upregulation of genes involved in stemness and leukemogenesis, with parallel downregulation of target genes of Gata1 and G...     »
Journal title abbreviation:
Blood Adv
Year:
2019
Journal volume:
3
Journal issue:
22
Pages contribution:
3729-3739
Fulltext / DOI:
doi:10.1182/bloodadvances.2019000761
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/31770439
Print-ISSN:
2473-9529
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie
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