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Title:

CARD-BCL-10-MALT1 signalling in protective and pathological immunity.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Review
Author(s):
Ruland, Jürgen; Hartjes, Lara
Abstract:
CARD protein-BCL-10-MALT1 (CBM) signalosomes are multiprotein signalling platforms that control immune and inflammatory pathways in most tissues. After exposure to distinct immune triggers, these molecules form self-organizing filaments with MALT1 protease activity to regulate canonical nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) signalling pathways and the degradation of mRNA-binding proteins, which provides two layers of control of inflammatory gene expression. These...     »
Journal title abbreviation:
Nat Rev Immunol
Year:
2019
Journal volume:
19
Journal issue:
2
Pages contribution:
118-134
Fulltext / DOI:
doi:10.1038/s41577-018-0087-2
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/30467369
Print-ISSN:
1474-1733
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie
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